• Artículo
      Icon

      A quantitative principle to understand 3D cellular connectivity in epithelial tubes 

      Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Anbari, Samira; Tagua Jáñez, Antonio; Gordillo Vázquez, Carmen María; Palacios, Ana M.; Velasco, Antonio; Capitán Agudo, Carlos; Grima Ruiz, Clara Isabel; Robles Arias, Rafael; Márquez Pérez, Alberto; Buceta, Javier; Escudero Cuadrado, Luis María; Annese, Valentina (Cell Systems, 2022)
      Apico-basal cell intercalations (scutoids) optimize packing and energy expenditure in curved epithelia. Further consequences ...
    • Artículo
      Icon

      Author Correction: Scutoids are a geometrical solution to three-dimensional packing of epithelia 

      Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Tagua Jáñez, Antonio Jesús; Forja, Cristina; Castro Rodríguez, Ana María; Grima Ruiz, Clara Isabel; Bermúdez Gallardo, Marina; Márquez Pérez, Alberto; Escudero Cuadrado, Luis María (Nature Research, 2018)
    • Artículo
      Icon

      CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia 

      Andrés San Román, Jesús Ángel; Gordillo Vázquez, Carmen María; Franco Barranco, Daniel; Morato Concejero, Laura; Huertas Fernández-Espartero, Cecilia; Baonza, Gabriel; Tagua Jáñez, Antonio Jesús; Vicente Munuera, Pablo; Palacios Barea, Ana María; Gavilán Dorronzoro, María de la Paz; Martín Belmonte, Fernando; Annese, Valentina; Gómez Gálvez, Pedro; Arganda Carreras, Ignacio; Escudero Cuadrado, Luis María (Elsevier, 2023)
      Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell ...
    • Artículo
      Icon

      EpiGraph: an open-source platform to quantify epithelial organization 

      Vicente Munuera, Pablo; Gómez Gálvez, Pedro; Tetley, Robert J.; Forja Barbosa, Cristina; Tagua Jáñez, Antonio Jesús; Letrán, Marta; Tozluoglu, Melda; Mao, Yanlan; Escudero Cuadrado, Luis María (Oxford University Press, 2020)
      Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational ...
    • Artículo
      Icon

      Evolutionary 3D Image Segmentation of Curve Epithelial Tissues of Drosophila melanogaster 

      Capitán Agudo, Carlos; Pontes Balanza, Beatriz; Gómez Gálvez, Pedro; Vicente Munuera, Pablo (MDPI, 2021)
      Analysing biological images coming from the microscope is challenging; not only is it complex to acquire the images, but ...
    • Artículo
      Icon

      Mechanics and self-organization in tissue development 

      Gómez Gálvez, Pedro; Anbari, Samira; Escudero Cuadrado, Luis María; Buceta, Javier (Elsevier, 2021)
      Self-organization is an all-important feature of living systems that provides the means to achieve specialization and ...
    • Artículo
      Icon

      Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy 

      Piñol Jurado, Patricia; Suárez Calvet, Xavier; Fernández Simón, Esther; Gallardo, Eduard; Gómez Gálvez, Pedro; Escudero Cuadrado, Luis María; Díaz Manera, Jordi (Nature Publishing Group, 2018)
      Duchenne muscle dystrophy (DMD) is a genetic disorder characterized by progressive skeletal muscle weakness. Dystrophin ...
    • Artículo
      Icon

      Non-productive angiogenesis disassembles Aß plaque-associated blood vessels 

      Álvarez Vergara, Maria I.; Rosales Nieves, Alicia E.; March Díaz, Rosana Rocío; Rodríguez Perinan, Guiomar; Lara Ureña, Nieves; Ortega de San Luis, Clara; Sánchez García, Manuel A.; Martín Bornez, Miguel; Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Fernández Gómez, Beatriz; Marchena, Miguel Ángel (Springer Nature, 2021)
      The human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature ...
    • Artículo
      Icon

      Rules of tissue packing involving different cell types: human muscle organization 

      Sánchez Gutiérrez, Daniel; Sáez Manzano, Aurora; Gómez Gálvez, Pedro; Paradas López, Carmen ‎; Escudero Cuadrado, Luis María (Nature Publishing Group, 2017)
      Natural packed tissues are assembled as tessellations of polygonal cells. These include skeletal muscles and epithelial ...
    • Artículo
      IconIcon

      Scutoids are a geometrical solution to three-dimensional packing of epithelia 

      Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Tagua Jáñez, Antonio; Forja Barbosa, Cristina; Castro Rodríguez, Ana María; Letrán, Marta; Grima Ruiz, Clara Isabel; Bermúdez Gallardo, Marina; Serrano Pérez-Higueras, Óscar; Márquez Pérez, Alberto; Escudero Cuadrado, Luis María (Nature Publishing Group, 2018)
      As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the ...
    • Tesis Doctoral
      Icon

      Scutoids unveil the three-dimensional packing in curved epithelia 

      Gómez Gálvez, Pedro (2020-07-16)
      As animals develop, the initial simple planar epithelia of the early embryos must acquire complex three-dimensional ...
    • Artículo
      Icon

      The complex three-dimensional organization of epithelial tissues 

      Gómez Gálvez, Pedro; Vicente Munuera, Pablo; Anbari, Samira; Buceta, Javier; Escudero Cuadrado, Luis María (The Company of Biologists Ltd., 2021)
      Understanding the cellular organization of tissues is key to developmental biology. In order to deal with this complex ...